Hormone Therapy In Menopause
Hormone Therapy In Menopause – With age, the body of every woman there, comes a natural transition period during which the predominant reverse the processes of development of the reproductive system. This period is called the menopause, characterized by a gradual fading of the hormonal function of ovaries. The result of the changes is the menopause – the last independent of menstruation, which judged in retrospect, after a month there is no year.
Menopause can be divided into pre-menopausal women, continuing from the beginning of irregular menstrual bleeding to the last menstrual period physiological and postmenopausal, starting one year after the monthly and continued until the end of a woman’s life. The time, combining pre-menopausal women, and the first year after the last menstrual period, called the menopausal transition.
Menopause occurs when
In a normal cyclical change in menstruation and termination occur at the age of 44-55 years. It is considered premature menopause before the fortieth anniversary, and violation of the regular rhythm of menstruation, followed by their extinction after 55 years usually attributed to a late menopause. Most often, menopause observed from 49 to 52 years.
The increase in life expectancy, according to a recently led to the fact that a tenth of the total female population of the planet constitutes the representatives of the older generation who are postmenopausal. It is, therefore, the significant problem of maintaining the health of this category of socially active society.
In the clinic, “New Life” are receiving skilled obstetricians specializing in endocrinology and anti-aging therapy (anti-aging). We help our patients avoid early menopause and overcome menopause without complications to health. Do all women menopause is a hormone replacement therapy? How to prevent cancer during this period? Can I take phytoestrogens with thyroid disease? Whether the weight influences, smoking, alcohol on the course of menopause? All of these questions your doctor may answer, Laboratory and instrumental patient study in our clinic.
Especially when hormonal menopause
Of the two million oocytes present in the ovaries of a newborn girl to the age of fifty is less than a thousand, it is not enough to carry out cyclic hormonal changes necessary for menstruation.And it is the depletion of the follicular unit is the basis of reproductive aging.
Reducing the number of follicles begins well before menopause – from 36-38 years, even when there are no clinical manifestations. An early indication of menopause is the growth level of FSH (stimulating follicle hormone). As the amount of data for 40-45 cycles without ovulation, and hence without the formation of the corpus luteum full, broken progesterone synthesis, which leads to failure of the second phase of the cycle and the relative increase in estrogen levels. This manifested by alternating delays of varying duration with monthly uterine bleeding.
Gradually elongates the interval between periods, progesterone levels fall more, a relative increase of estrogen replaced total extinction of their synthesis, increased FSH and LH (luteinizing hormone) to the level characteristic of the absence of monthly period. After menopause, the amount of LH increases three times, and FSH – more than ten as compared to the transitional stage. This is the case for about three years after the cessation of menstruation, and then levels of these hormones are gradually falling, remaining still above normal.
In postmenopausal women, the ovaries almost do not synthesize estrogen and progesterone and estradiol and estrone, determined in serum, formed in the fatty tissue of the adrenal androgens origin. Therefore, the more fat tissue, the higher the level of estrogen. In the absence of progesterone is significant increases the risk of hyperplastic processes and malignant tumors of the uterine body. Over the same low levels of serum estrogens in women with underweight provokes osteoporosis and fractures.
Dangers of transition
Most of our patients are feeling the fading of ovarian hormonal function as a series of characteristic symptoms. Most often it is Vegetosovascular symptoms described by the term “hot flashes.” These include excessive sweating, the sensation of heat, redness of the skin, especially the face and neck. Women suffer irritability, tearfulness, difficult to fall asleep, a tendency to depression.
Dysuria, urinary incontinence, frequent recurrence of vaginal inflammatory diseases, disorders of original plan reduces the quality of life of women in this age period. But it is much more dangerous complications are considered growth and blood pressure instability. The tendency to tumor processes and the development of osteoporosis.
Hormone therapy goals
The treatment called substitution implies the elimination of menopausal complications preparations containing synthetic female sex hormones. Substitution fading ovarian functional activity is the aim of this treatment, which can be carried out:
- short-term – up to 1.5-2 years in neuro and urological manifestations;
- Long-Term – 2-5 years or more are at high-risk osteopenia and cardiovascular disorders. Also, the holding of such therapy significantly reduces the likelihood of colorectal cancer (cancer of the large intestine).
The principles of selection of hormones during menopause
Individual approach and consideration of all criteria (age, physique and body weight, comorbidities, family history through the female line).
Receiving combined preparations containing estrogen except for progestogen component, it is possible in a cyclic mode and monophasic. When cycling there spotting the type of menstruation, when monophasic mode – not, as more progestogen leads to atrophy of the endometrium. This mode recommended not earlier than in 1-1, five years after the cessation of menses.
A survey in the appointment of hormones
The doctor of our clinic before you assign hormonal preparations, be sure to recommend and carry out:
- collecting anamnestic data (information on heredity, and transferred the list structure for lifestyle diseases, information about taking oral contraceptives and the response to them, etc.);
- gynecological examination and taking a swab Oncocytological;
- Pelvic ultrasound with the measurement of thickness and the description the structure of the endometrium;
- Breast ultrasound or mammography;
- Clinical, biochemical analyses of blood clotting assay;
- determining the level of FSH and LH, estradiol, thyroid hormones;
- physical examination with measurement of blood pressure and heart rate;
- determination of bone mineral density;
- counseling related professionals.
Why do I need to see a doctor?
Menopause – one of the most difficult in a woman’s life. The organism rearranged, providing reproductive period ability to reproduce; during the menopause, the body redistributes the role of hormones, and, unfortunately, not always very clear, as we would like. The loss of minerals, reduction of endogenous enzymes. And vitamins have an adverse impact on the health of women and men. Only in-depth knowledge of doctors will help to safely pass this period and move to the older age group in a good, healthy body.